![]() ![]() The extent to which immunologic factors influence meningioma etiology has been largely unexplored. Because women are twice as likely as men to develop meningiomas and these tumors harbor hormone receptors, an etiologic role for hormones (both endogenous and exogenous) has been hypothesized. ![]() High dose ionizing radiation exposure is an established risk factor for meningioma, and lower doses may also increase risk, but which types and doses are controversial or understudied. People with certain mutations in the neurofibromatosis gene ( NF2) have a very substantial increased risk for meningioma. Inherited susceptibility to meningioma is suggested both by family history and candidate gene studies in DNA repair genes. They are the most frequently diagnosed primary brain tumor accounting for 33.8% of all primary brain and central nervous system tumors reported in the United States between 20. Although most meningiomas are encapsulated and benign tumors with limited numbers of genetic aberrations, their intracranial location often leads to serious and potentially lethal consequences.
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